“Exercise starts and ends in the brain”: this was the title of a review article authored by Dr. Bengt Kayser back in 2003. In this piece of work, the author highlights that pioneer studies have primarily focused on the cardiorespiratory-muscle axis to set the human limits to whole-body exercise tolerance. In some circumstances, however, exercise cessation may not be solely attributable to these players: the central nervous system is thought to hold a relevant role as the ultimate site of exercise (...) termination. In fact, there has been a growing interest relative to the “brain” response to exercise in chronic cardiorespiratory diseases, and its potential implication in limiting the tolerance to physical exertion in patients. To reach these overarching goals, non-invasive techniques, such as near-infrared spectroscopy and transcranial magnetic stimulation, have been successfully applied to get insights into the underlying mechanisms of exercise limitation in clinical populations. This review provides an up-to-date outline of the rationale for the “brain” as the organ limiting the tolerance to physical exertion in patients with cardiorespiratory diseases. We first outline some key methodological aspects of neuromuscular function and cerebral hemodynamics assessment in response to different exercise paradigms. We then review the most prominent studies, which explored the influence of major cardiorespiratory diseases on these outcomes. After a balanced summary of existing evidence, we finalize by detailing the rationale for investigating the “brain” contribution to exercise limitation in hitherto unexplored cardiorespiratory diseases, an endeavor that might lead to innovative lines of applied physiological research. (shrink)

The MS. hie tunc of V. 6 has no friends. L. Mueller's hoc tunc is weak and flat, and L. Rank, Mnemosyne 40. 51, is justly dissatisfied with the hietans of M. Havet's larger and smaller editions, to which the hians of Verg. Aen. 12. 754 lends no sufficient support, as there the dog is opening its mouth before it bites. Add to this that it is by no means certain that Phaedrus would either have used the word or used (...) it in the simple sense of opening the mouth. Rank's own proposal, ‘heu’ tunc, fails also to carry conviction. There is however a word which belongs to our author's vocabulary and is as near to the manuscripts as either of the above, and which hits the sense at which hietans aims. This is rictus. The word is often used of the opened mouths of dogs, Lucr. 5. 1064, Ovid Met. 13. 568. Juvenal 10. 271 sq. ‘canino latrauit rictu,’ and of other animals. That it is appropriate with dimisit ‘let go’ may be seen from the counterpart expression of Martial 1. 48. 1 ‘rictibus his tauros non eripuere magistri.’. (shrink)

The MS. hie tunc of V. 6 has no friends. L. Mueller's hoc tunc is weak and flat, and L. Rank, Mnemosyne 40. 51, is justly dissatisfied with the hietans of M. Havet's larger and smaller editions, to which the hians of Verg. Aen. 12. 754 lends no sufficient support, as there the dog is opening its mouth before it bites. Add to this that it is by no means certain that Phaedrus would either have used the word or used (...) it in the simple sense of opening the mouth. Rank's own proposal, ‘heu’ tunc, fails also to carry conviction. There is however a word which belongs to our author's vocabulary and is as near to the manuscripts as either of the above, and which hits the sense at which hietans aims. This is rictus. The word is often used of the opened mouths of dogs, Lucr. 5. 1064, Ovid Met. 13. 568. Juvenal 10. 271 sq. ‘canino latrauit rictu,’ and of other animals. That it is appropriate with dimisit ‘let go’ may be seen from the counterpart expression of Martial 1. 48. 1 ‘rictibus his tauros non eripuere magistri.’. (shrink)

So in this outburst of Cornelia should line 104 be punctuated. For the poenas crudelis compare VII. 431 ‘quod semper saeuas debet tibi Parthia poenas’ and Verg. A. 6. 501 quis tam crudelis optauit sumere poenas? whence, or from ib. 585, ‘uidi et crudelis dantem Salmonea poenas’ we may suppose Lucan derived it. The feeble vulgate punctuation which puts the comma after crudelis, supposed to be vocative, well exemplifies the mischievous influence of propinquity.—I now find the correct punctuation in W. (...) E. Weber's Corpus, but with the needless alteration of crudel e s. (shrink)

A dictionary definition of Bioethics is, 'the ethics, or moral principles and rules of conduct, of medical and biological research'. This book is an introductory text of just biological and not medical bioethics. It covers the ethics of experimentation, including genetic manipulation, in plants and animals; ethics and biodiversity, ethics and the environment. There is increasing interest in bioethics - both in academia and by the media and the general public. Awareness of bioethics is incorporated into Biological / Environmental Science (...) courses, plus the first dedicated modular courses on bioethics are starting up. * Includes case studies * Has questions for students * Chapters include environmental, animal, agricultural and reproductive ethics as well as a wide range of issues regarding genetic manipulation. (shrink)

In this response, the Australian Health Ethics Committee (AHEC) indicates that it shares, and has strategies in place to address, the majority of the concerns identified by Susan Dodds. AHEC believes it is too early to assess the full impact of the National Statement on Ethical Conduct in Research Involving Humans (1999) or to call for a major review of the ethics committee process. While some Human Research Ethics Committees (HRECs) are over-stretched, the system is not on the verge of (...) collapse. (shrink)

v. 1. Nicomachean ethics. Politics. The Athenian Constitution. Rhetoric. On Poetics.--v. 2. Logic.--v. 3. Physics. Metaphysics. On the soul. Short physical treaties.--v. 4. On the heavens. On generation and corruption. Meteorology. Biological treatises.

The doctrine of the Incarnation, that Jesus Christ was both truly God and truly human, is the foundation and cornerstone of traditional Christian theism. And yet this traditional teaching appears to verge on incoherence. How can one person be both God, having all the perfections of divinity, and human, having all the limitations of humanity? This is the fundamental philosophical problem of the Incarnation. Perhaps a solution is found in an analysis of what the traditional teaching meant by person, divinity, (...) and humanity, or in understanding how divinity and humanity were united in a single person. This Element presents that traditional teaching, then returns to the incoherence problem to showcase various solutions offered to it. (shrink)

When Charles Darwin (1859, 482) wrote in the Origin of Species that he looked to the “young and rising naturalists” to heed the message of his book, he likely had in mind individuals like Ernst Haeckel (1834-1919), who responded warmly to the invitation (Haeckel, 1862, 1: 231-32n). Haeckel became part of the vanguard of young scientists who plowed through the yielding turf to plant the seed of Darwinism deep into the intellectual soil of Germany. As Haeckel would later observe, the (...) seed flourished in extremely favorable ground. The German mind, he would write (1868), was predisposed to adopt the new theory. The great philosopher Immanuel Kant (1724- 1804), for instance, was on the verge of accepting a transmutational view in his Third Critique (1790; 1957, 538-39), though he stepped gingerly back from the temptation. Johann Wolfgang von Goethe (1749-1832), about the same time, dallied with transmutational ideas, at least Haeckel would convince Darwin that the Englishman had an illustrious predecessor. Jean-Baptiste de Lamarck’s (1744-1829) conceptions had taken hold among several major German thinkers in the first few decades of the nineteenth century in a way they had not in England and France. Among those ready to declare themselves for the new dispensation was Rudolf Virchow (1821-1902), Haeckel’s teacher at Würzburg—though, this very political scientist would prove Haeckel’s nemesis later in the century. So Haeckel’s estimate of the ripeness of German thought was not off the mark. Darwinism took hold in the newly unified land, though not without some struggle; but at last it became the dominant view in the biological sciences. But with its success did it foster the malign racist ideology that transfixed Adolf Hitler (1889-1945)? (shrink)

Establishment holds that thc psychological mechanism of inference is the ment psychological thcorizing. Moreover, given this conciliatory reading, transformation of mental representations, it follows that perception is in.

Extant semantic theories for languages containing vague expressions violate intuition by delivering the same verdict on two principles of classical propositional logic: the law of noncontradiction and the law of excluded middle. Supervaluational treatments render both valid; many-Valued treatments, Neither. The core of this paper presents a natural deduction system, Sound and complete with respect to a 'mixed' semantics which validates the law of noncontradiction but not the law of excluded middle.

The wine referred to in the second line of the epigram was produced near Verona, at the foot of the Rhaetian Alps. It was well regarded by most and was a favourite of the Emperor Augustus: for references see Mynors at Verg. G. 2.96 and my note at Mart. 14.100.2. It appears, however, to have undue prominence in this poem, supposedly about the earthenware drinking vessels which, presumably, were manufactured in the same area. There is also the question of why (...) Martial refers to Verona in such a circumlocutory way. Is he merely following a well established elegiac/epigrammatic convention in associating Verona with Catullus , or does his circumlocution here have any particular point? (shrink)

I do not for a moment question the fact that many people have experiences of a special type which may be termed “religious”, The extent to which religious experience may be regarded as a reasonably common phenomenon in present-day Britain is shown clearly by David Hay in his Exploring Inner Space, Harmondsworth 1982. that such experiences often involve reference to something which appears to display a radical unlikeness to all else and that they are therefore in some sense inexpressible. Doubtless (...) the ideas I have put forward about the possible source of such unlikeness and ineffability might suggest models of God which would not find much theological approval, at least within any mainstream theistic tradition, since some sort of pantheism seems inevitably to be implied. But however this might be, the concept of radical unlikeness as it has been analyzed here can, I think, help us towards understanding certain problematic areas in religion quite apart from the issue of intelligibility, which has been the focus of this discussion. To begin with, radical unlikeness suggests a way in which the historical continuity of concepts of the transcendent might be upheld against the discontinuity suggested by the diversity of interpretations through which they have moved. Ancient and modern outlooks on, say, God differ enormously, as indeed do the range of co-temporal accounts at many particular moments. But, by and large, theologians firmly maintain that it is a single and unchanging phenomenon which is being dealt with. Unless we can point to some common element which is both specific enough to create a binding sense of common tradition, yet never completely expressed by any attempt at understanding it within that tradition (thus persistently demanding new attempts to apprehend it), then given the widely differing views of God within, for example, the Christian community, it is difficult to see how we could assume that in fact they all stemmed from the same source and were talking about the same thing. The idea of radical unlikeness could provide an element with just these required characteristics: it could be seen as what all the accounts attempt to net, with varying degrees of adequacy, within their offered interpretations. It could be seen as what remains constant, constantly elusive yet constantly generative of fresh attempts to apprehend it, throughout a history of intra-religious diversity. This sort of explanation could, presumably, be applied to the intra-religious diversity of the non-Christian traditions too.Secondly, radical unlikeness might suggest a possible way of understanding inter-religious diversity in a way which allows that whilst such diversity exists, whilst the differences between religions are real, they are grounded in a similar root-experience. It may, at first sight, seem difficult to continue thinking of the various religious traditions as truly separate phenomena if they are taken as being grounded on experiences whose ineffability stems from the unlikeness of experiencing things as a whole. Here we must stress again that if they are to be considered intelligible, radically unlike experiences cannot be considered completely so - or putting this another way, we cannot more than approach experience of totality. Sense can be given to religious claims of ineffability by suggesting experience of near totality, where we reach the last point on the scale of inclusiveness which complies with the logical criteria demanded of something for it to be possible for us to be aware of it. We might thus attempt an explanation of inter-religious diversity based on the view that Hinduism, Buddhism, Christianity, Islam etc. acquire their differences from the different elements included in their experience of near totality. Taking totality to be represented by the scale of one to ten, Hinduism might be seen as grounded on experience of 1-2-3-4-5-6-7-9-10, Buddhism on experience of 1-3-4-5-6-7-8-9-10 and so on. The resulting dissimilarities are thus centred not on different types of experience, but on different areas of inclusiveness. This is, of course, to suppose that the various religious traditions are all based on the same degree (as opposed to the same elements) of inclusiveness, but it is by no means clear that such a supposition is justified. Continuing with our decimal analogy, might it not be suggested that whilst Christianity stemmed from experience of 2-3-4-5-6-7-8-9-10, Jainism was founded on a less extensive encounter with the divine (say 4-5-6-7-8-9-10)? It is, however, uncertain how we can compare and evaluate different religious traditions in such a way as to be able to comment on such claims. A definite danger of comparative religion is that by concentrating on establishing and exploring inter-religious likenesses, it may obscure the radical unlikeness of religious phenomena. It should be borne firmly in mind that such likenesses as may be established within comparative studies may not win religious phenomena a place within our understanding comparable to objects of more everyday concern. Statements found in the Old Testament, the Qur'an and the Vedas, for example, may, on occasion, be alike, but at the end of the day such things are often alike only, or chiefly, in so far as they display the same radical unlikeness in relation to the non-religious elements in our outlook.The analysis of radical unlikeness and ineffability which has been advanced might also suggest a way in which certain passages in religious writings could be understood, passages which at first sight can be seriously perplexing. If, for example, to return to the quotation given in the introductory section of this paper, we continue to think of accounts of the nature of Shiva as being attempts to describe some discrete, objective entity, then it is inevitable that either we will share the Puranic writer's puzzlement or that much of what we read about Shiva will appear as the muddled and extravagant thinking thrown up by an uncritical and over-fertile mythological imagination, consisting of little more than a hotch-potch of contradictory elements. But if we see such accounts as attempting to say something about everything, as symbols of near totality stemming from experiences which verge on the holistic, then what we read - with all its ambiguities - may become somewhat more meaningful. Thus W.D. O'Flaherty comments that Shiva “embodies all of life in all its detail at every minute” (Asceticism and Eroticism in the Mythology of Shiva, London 1973, p. 315). Similarly Alain Dani41ou sees Shiva, ultimately, in terms of his being "the supreme state of reality" beyond whom there is only "non-existence" (Hindu Polytheism, London 1964, p. 190).This analysis of ineffability and intelligibility seeks to introduce for debate a possible way of understanding the radical unlikeness which accounts of religious experience apparently attempt to speak about. It does not, however, claim to present an exhaustive treatment of the issues raised, on the contrary, I am conscious of many shortcomings and omissions. For instance, it remains to be seen under precisely what conditions something counts as being an elucidating likeness (presumably all experiences are, for example, temporal, yet temporality alone would not seem to offer a particularly elucidating comparison). Moreover, the degree to which appeal to likeness is allowed operation in actual accounts of religious experience needs to be explored. In addition, the notion of categorizing experiences according to the extent to which they approach a point of total inclusion requires careful clarification. To begin with, according to what criteria could we establish that one experience was more inclusive than another? However, such issues can only be mentioned here, any adequate consideration of them would require a separate paper.In conclusion, I would suggest that to use radical unlikeness and/or ineffability simply as devices by which to halt any process of investigation, proclaiming that the thing in question is not like anything and so is beyond all words, risks making unintelligible and placing beyond all further inquiry an important and extensive area of human experience. As William Alston put it, to label something ineffable in an unqualified way is to shirk the job of making explicit the ways in which it can be talked about. William P. Alston, “ineffability”, Philosophical Review 65 (1956), 522. It is surely more accurate to take ineffability as a “qualifier”I.T. Ramsey, Models and Mystery (Oxford 1964), p. 60. which “multiplies models without end”Ibid. than as an absolute which prevents the construction of any elucidating models. (shrink)

Whenever some form of beneficent killing--for example, voluntary euthanasia--is advocated, the proposal is greeted with a flood of slippery-slope arguments warning of the dangers of a Nazi-style slide into genocide. This paper is an attempt systematically to evaluate arguments of this kind. Although there are slippery-slope arguments that are sound and convincing, typical formulations of the Nazi-invoking argument are found to be seriously deficient both in logical rigour and in the social history and psychology required as a scholarly underpinning. As (...) an antidote, an attempt is made both to identify some of the likely causes of genocide and to isolate some of the more modest but legitimate fears that lie behind slippery-slope arguments of this kind. (shrink)

At least since the seminal work of the (US) National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research in the 1970s, a fundamental distinction between research and practice has underwritten both conceptual work in research ethics and regulations governing research involving human subjects. Notwithstanding its undoubted historical importance, I believe the distinction is problematic because it misrepresents clinical inquiry. In this essay, I aim to clarify the character of clinical inquiry by identifying crucial contextual constraints on (...) justification constitutive of clinical science. This analysis shows that, from an epistemological point of view, clinical research and clinical practice are not sharply distinct but intimately intertwined. This result is important in its own right—an enriched understanding of the epistemology of clinical research is valuable in and of itself. But this result is also important because it has profound implications for the ethics of human subjects research. (shrink)

I aim to show how and why some definitions can be benignly circular. According to Lloyd Humberstone, a definition that is analytically circular need not be inferentially circular and so might serve to illuminate the application-conditions for a concept. I begin by tidying up some problems with Humberstone's account. I then show that circular definitions of a kind commonly thought to be benign have inferentially circular truth-conditions and so are malign by Humberstone's test. But his test is too demanding. The (...) inferences we actually use to establish the applicability of, e.g., colour concepts are designed to establish warranted assertability and not truth. Understood thus, dispositional analyses are not inferentially circular. (shrink)

Although this note is prompted by the recent exchange between Gellner [2], [3] and Needham [4], I shall ignore the issues raised by Gellner's specification for an ideal language. I am concerned here only with Needham's statement that ‘biology is one matter and descent is quite another, of a different order’ which, it will be remembered, Gellner treats as Needham's first error. I write under a sense of obligation, for I discussed this matter with Gellner in 1955 while he was (...) preparing his first article and my arguments then were phrased similarly to those advanced by Needham. It appears that I did not make myself clear to Gellner and I shall try again. I do not wish to attack or defend either protagonist; each is quite able to look after himself. Therefore I propose neither to examine where they have misunderstood each other, nor to discuss the difference between kinship and descent, but simply to state the connexion, as I see it, between physical and social kinship. (shrink)

The paper discusses the critical importance of interdependence and team development for the devel opment of human values, humane organizations, and sustainable earth management. The paper accords priority to the cultivation and nurturance of this spirit over TQM, reengineering, strategic management and the like. While not denying the practical need for hierarchy, specialization and discipline, the paper argues that it is the one-sided emphasis on such features which has aggravated fragmentation in organizations, militating against interdependent teamwork.

In The Face of Emotions, which was Carroll Izard’s first major attempt at elaborating his differential emotions theory, he stated that the book “presents a theoretical framework for the study of emotions and their role in personality and interpersonal processes.” Yet, over the years, his contribution to personality theory has generally been overshadowed by the attention focused on his views on facial expressions and the structure of emotions. This article will begin with a brief overview of the DET perspective on (...) personality development. Then, it will examine how the DET framework can be used to organize recent findings from three lines of research on adult personality. It will conclude with suggestions for future research as well as some personal recollections. (shrink)

On the verge of the one hundredth anniversary of the founding of the American Association of University Professors, we examine the organization’s focus on academic freedom, shared governance, and the challenges the AAUP faced during its early years. The history is a fairly uncontested one: higher education in the late nineteenth and early twentieth centuries in the United States was the context for the struggle over academic freedom and shared governance. Dismissed professors, resignations by colleagues, and the struggle of professionalization (...) characterize the period.1 A century later, we wonder about the state of academic freedom and shared governance. We argue that higher education is currently so.. (shrink)

In the Spring of 1944, an informal discussion took place in Cambridge between Mr. R. S. Whipple, Professor Allan Ferguson and Mr. F. H. C. Butler, concerning the formation of a national Society for the History of Science. This is the opening sentence of the inaugural issue of the Bulletin of the British Society for the History of Science, the Society's first official publication. Butler himself was the author of this outline account of the subsequent approach to the Royal Society, (...) the parallel moves to establish a National Committee of the International Academy of the History of Science, the formation of a provisional committee to prepare a draft constitution for a national society, and the proceedings of the first Annual General Meeting in May 1947. Whipple had been in Cambridge to discuss his offer to present his collection of old scientific instruments to the University and the possible foundation of a new museum, and Butler, as Secretary of the History of Science Committee in Cambridge, was the chief mover in both this development and an initiative coupled with it to establish a department of the history of science. (shrink)

The essays collected together in this volume, many of them written by leading scholars in the field, explore the commonsensical fact that our presence as..

Amyloid-beta peptide plaque in the brain is the primary diagnostic criterion of Alzheimer's disease . The physiological role of Abeta are poorly understood. We have previously determined an Abeta interacting domain in the promoters of AD-associated genes . This AbetaID interacts in a DNA sequence-specific manner with Abeta. We now demonstrate novel Abeta activity as a possible transcription factor. Herein, we detected Abeta-chromatin interaction in cell culture by ChIP assay. We observed that human neuroblastoma cells treated with FITC conjugated Abeta1-40 (...) localized Abeta to the nucleus in the presence of H2O2-mediated oxidative stress. Furthermore, primary rat fetal cerebrocortical cultures were transfected with APP and BACE1 promoter-luciferase fusions, and rat PC12 cultures were transfected with polymorphic APP promoter-CAT fusion clones. Transfected cells were treated with different Abeta peptides and/or H2O2. Abeta treatment of cell cultures produced a DNA sequence-specific response in cells transfected with polymorphic APP clones. Our results suggest the Abeta peptide may regulate its own production through feedback on its precursor protein and BACE1, leading to amyloidogenesis in AD. (shrink)

In his recent paper Gellner singles me out for special comment and some reply is called for. He attributes to me several propositions which he says I made in my note on ‘Physical and social kinship’ in this journal, and he then refutes them. Reading his paper I cannot avoid thinking that he exaggerates the differences between us, thereby apparently strengthening his argument. Some substantial differences there are, but others are fictional. A line-by-line analysis of what he says about me (...) in his paper might be amusing but would be of only ephemeral interest. In this reply I confine myself to a few important issues. (shrink)

What follows is a discussion, in three parts, of the African concept of ubuntu and related issues. In the first part of the discussion J.A.I. Bewaji assesses an essay by W.M.J. van Binsbergen on Ubuntu and the Globalisation of Southern African Thought and Society (2001). In the second part Bewaji reviews M.B. Ramose's African Philosophy through Ubuntu (2002). And in the third part Ramose responds to both Bewaji and Van Binsbergen. Although Ramose disagrees with some of Bewaji's comments and interpretations (...) – especially with regard to the thesis on which ubuntu is, according to the former, founded (i.e. “that ontology proper is a rheology”) – both Bewaji and Ramose agree that Van Binsbergen's critique of ubuntu philosophy, and specifically of Ramose's explication thereof, is untenable. S. Afr. J. Philos. Vol.22(4) 2003: 378-414. (shrink)

The rule of double effect is regularly invoked in ethical discussions about palliative sedation, terminal extubation and other clinical acts that may be viewed as hastening death for imminently dying patients. Unfortunately, the literature tends to employ this useful principle in a fashion suggesting that it offers the final word on the moral acceptability of such medical procedures. In fact, the rule cannot be applied appropriately without invoking moral theories that are not explicit in the rule itself. Four tenets of (...) the rule each require their own ethical justification. A variety of moral theories are relevant to making judgements in a pluralistic society. Much of the rich moral conversation germane to the rule has been reflected in arguments about physician-asssisted suicide and voluntary active euthanasia, but the rule itself has limited relevance to these debates, and requires its own moral justifications when applied to other practices that might hasten death. (shrink)